Papers And Originals

Prostaglandin-oxytocin Enhancement and Potentiation and their Clinical Applications

Br Med J 1972; 1 doi: (Published 15 January 1972) Cite this as: Br Med J 1972;1:150
  1. Arnold Gillespie


    The pharmacological phenomena of enhancement and potentiation of uterine response occur respectively when combinations of some prostaglandins and oxytocin are given serially and simultaneously to a patient. Employing these phenomena allows small doses of the drugs to achieve the same effects as a large dose given alone. In a pilot study of the use of the combination of prostaglandin and oxytocin for the induction of mid-trimester abortion seven of nine women were aborted within 48 hours. Side effects attributable to prostaglandin were eliminated or reduced in severity.