Papers And Originals

Chronic Liver Disease and Mitochondrial Antibodies: A Family Study

Br Med J 1972; 1 doi: https://doi.org/10.1136/bmj.1.5793.146 (Published 15 January 1972) Cite this as: Br Med J 1972;1:146
  1. J. G. Walker,
  2. D. Bates,
  3. D. Doniach,
  4. P. A. J. Ball,
  5. S. Sherlock

    Abstract

    Two sisters had primary biliary disease and associated autoimmune thyroiditis with high titres of mitochondrial and other autoantibodies. Their deceased mother possibly suffered from similar disorders. In the same family two brothers had multiple autoimmune reactions, including mitochondrial antibodies, but liver function tests gave normal results. Ten other close relatives were investigated. Australia antigen was not found in the proband or her relatives.