Papers And Originals

Changes in Total Body Calcium and Sodium in Osteomalacia

Br Med J 1972; 1 doi: (Published 01 January 1972) Cite this as: Br Med J 1972;1:19
  1. D. J. Hosking,
  2. M. J. Chamberlain,
  3. J. H. Fremlin,
  4. H. James


    Serial measurements were made of total body calcium and sodium, using whole body neutron activation analysis, in six patients being treated for osteomalacia. All showed a rise in total body calcium ranging from 3 to 30%; this continued for up to 24 months after the start of treatment, though complete healing had apparently occurred after 6 months on the basis of histological examination of biopsy specimens of bone. As the total body calcium rose there was a fall in the non-exchangeable sodium pool in bone.