Papers And Originals

Pulmonary Emphysema and α1-Antitrypsin Deficiency

Br Med J 1971; 1 doi: (Published 27 March 1971) Cite this as: Br Med J 1971;1:689
  1. D. C. S. Hutchinson,
  2. P. J. L. Cook,
  3. C. E. Barter,
  4. Harry Harris,
  5. P. Hugh-Jones


    Of 72 patients with radiological evidence of pulmonary emphysema, emphysema occurred either alone or in association with bronchitis in 61, and 8 of these (13%) were found to have α1-antitrypsin deficiency. The main features of this condition are: exertional dyspnoea of relatively early onset (generally between 30 and 45 years of age), severely impaired FEV1 and TLCO, and radiological emphysema predominantly affecting the lower zones of the lungs. It is probable that any patient with all the above abnormalities has α1-antitrypsin deficiency. There is evidence to suggest that cigarette smoking may hasten the onset of this type of emphysema.