Effect of Actinomycin D on Paget's Disease of BoneBr Med J 1971; 1 doi: https://doi.org/10.1136/bmj.1.5746.423 (Published 20 February 1971) Cite this as: Br Med J 1971;1:423
- James J. Fennelly,
- Joseph F. Groarke
Four patients with active Paget's disease were treated with the RNA inhibitor actinomycin D. Three were clinically improved after treatment; the fourth had multiple collapsed vertebrae and showed no symptomatic improvement. Striking changes took place in urinary calcium and hydroxyproline, in serum alkaline phosphatase, and to a less extent in serum calcium and phosphate. These studies are continuing and are being compared with the effects of mithramycin.