Papers And Originals

Two Populations of Rh Groups together with Chromosomally Abnormal Cell Lines in the Bone Marrow

Br Med J 1971; 1 doi: http://dx.doi.org/10.1136/bmj.1.5741.131 (Published 16 January 1971) Cite this as: Br Med J 1971;1:131
  1. Sheila T. Callender,
  2. H. E. M. Kay,
  3. Sylvia D. Lawler,
  4. Rosemary E. Millard,
  5. Ruth Sanger,
  6. Patricia A. Tippett

    Abstract

    At the onset of his disease a man with polycythaemia vera had chromosomally normal cells in the bone marrow and Rh blood group CDe/cDE. Five years later he developed pancytopenia with erythroid hyperplasia of the bone marrow. This was associated with the presence of a major abnormal clone, 45,XY,B-,C-,16+, a minor clone, 45,XY,2+,3-,C-, and a few apparently normal cells. At the same time Rh blood grouping showed two populations of red cells, one CDe/cDE and one giving the reactions of CDe/CDe which can be interpreted as CDe. If monosomic CDe be the correct interpretation the case provides a strong hint that the Rh complex locus is sited either on the long arm of a B-group chromosome or, less probably, on an autosome of the C group.