Papers And Originals

Intrinsic-factor Antibody and Absorption of Vitamin B12 in Pernicious Anaemia

Br Med J 1971; 1 doi: http://dx.doi.org/10.1136/bmj.1.5739.25 (Published 02 January 1971) Cite this as: Br Med J 1971;1:25
  1. M. S. Rose,
  2. I. Chanarin

    Abstract

    The mean urinary excretion in a vitamin-B12 absorption (Schilling) test in control subjects was 19·2% and in pernicious anaemia when given with additional intrinsic factor was as follows: no intrinsic-factor antibodies demonstrable 19·3%, antibodies in serum only 14·4%, antibodies in gastric juice only 11·1%, and antibodies in both serum and gastric juice 8·4%. It is concluded that intrinsic-factor antibody exerts an adverse effect on vitamin-B12 absorption in most patients with pernicious anaemia.