Phenformin in Insulin-Dependent DiabeticsBr Med J 1970; 1 doi: https://doi.org/10.1136/bmj.1.5697.660 (Published 14 March 1970) Cite this as: Br Med J 1970;1:660
- Arnold Bloom,
- R. J. Kolbe
Forty-one diabetic patients on insulin were given 100mg. of phenformin daily for six weeks, either before or after a period of six weeks of inert capsules, in a double-blind cross-over trial. Eleven patients while on phenformin noticed hypoglycaemic effects and reduced their insulin on average by almost 20% without resultant rise in blood sugar levels. Twenty-eight patients felt no untoward effects and maintained their usual insulin dose. Phenformin led to improved control of the diabetes, with a significant decrease in blood sugar levels and a significant reduction in the variability of the weekly blood sugar readings. There was no increased ketosis, no change in cholesterol, and no significant loss of weight.