Papers And Originals

Primary Amoebic Meningoencephalitis in Britain

Br Med J 1970; 1 doi: (Published 07 March 1970) Cite this as: Br Med J 1970;1:596
  1. J. Apley,
  2. S. K. R. Clarke,
  3. A. P. C. H. Roome,
  4. S. A. Sandry,
  5. G. Saygi,
  6. B. Silk,
  7. D. C. Warhurst


    Meningoencephalitis proved to be due to an amoeba (Naegleria) has been diagnosed in Great Britain for the first time. The first patient (a boy of 2) survived longer than any previously recorded cases, but in spite of early diagnosis and treatment he died 15 days after the onset of meningeal symptoms.

    Two other children who were exposed to the same possible source of infection (a warm, muddy puddle) had similar symptoms and developed mild meningitis. A naegleria was isolated from the cerebrospinal fluid of one of them. Both recovered after treatment with amphotericin.