Papers And Originals

Impaired Glucose Tolerance: A Late Effect of Insulin Shock Treatment

Br Med J 1970; 1 doi: (Published 21 February 1970) Cite this as: Br Med J 1970;1:465
  1. Richard Hunter,
  2. Muriel Jones,
  3. B. A. L. Hurn,
  4. Catherine Duncan


    Glucose tolerance tests were performed in a group of patients in a mental hospital who had been treated with insulin shock and in a matched control group. Five out of 31 (16%) patients in the insulin-treated group and 1 out of 22 (5%) controls had “diabetic” blood sugar curves. Median blood sugar values were significantly higher at 60 minutes and later in the insulin-treated group, as were mean blood sugar values when the “diabetic” patients were excluded. Small amounts of plasma insulin-binding antibody were found in two insulin-treated patients. In the absence of any other clear-cut explanation, it is suggested that in some patients massive doses of insulin by injection may leave diminished tissue responsiveness to insulin as a long-term after-effect.