Papers And Originals

Presence of Particles other than the Australia-SH Antigen in a Case of Chronic Active Hepatitis with Cirrhosis

Br Med J 1970; 1 doi: (Published 31 January 1970) Cite this as: Br Med J 1970;1:262
  1. A. J. Zuckerman,
  2. Patricia E. Taylor


    Examination of serum specimens from a patient with chronic active hepatitis proved negative to the Australia-SH antigen by immunodiffusion and by complement fixation. Because the sera were anticomplementary they were examined with the electron microscope, and virus-like structures similar to members of the coronavirus group were identified. The possible significance of this finding in human serum and its relation to mouse hepatitis virus are discussed.

    A sample of the serum pool containing the MS-1 agent was found negative when examined by immunodiffusion, complement fixation, and electron microscopy. The possible lack of immunological identity between infectious and serum hepatitis is discussed.


    • * Part of a paper presented at a meeting on laboratory tests for hepatitis, National Research Council, Washington, October 1969.