Effect of Ergotamine and Ergometrine on Forearm Venous Compliance in ManBr Med J 1970; 1 doi: http://dx.doi.org/10.1136/bmj.1.5689.139 (Published 17 January 1970) Cite this as: Br Med J 1970;1:139
- O. G. Brooke,
- B. F. Robinson
The effect of ergotamine and ergometrine on the venous compliance of the forearm has been studied in normal persons. Ergotamine tartrate (0·25 mg. intravenously) led to a fall in venous compliance amounting to 49% on average, while ergometrine maleate (0·25 mg. intravenously) caused a reduction of 41%; these changes were statistically significant. The potent veno-constrictor action of these ergot alkaloids appears to be a major component of the circulatory response to small doses and may be important in provoking the harmfull cardiovascular side-effects (such as angina and pulmonary oedema) that are sometimes observed in patients with pre-existing heart disease.