Papers And Originals

Correlation of Serum and Urine Vitamin B12

Br Med J 1970; 1 doi: https://doi.org/10.1136/bmj.1.5689.138 (Published 17 January 1970) Cite this as: Br Med J 1970;1:138
  1. J. F. Adams

    Abstract

    The relation between the serum vitamin B12 level and the daily loss of vitamin B12 in urine was examined in patients with normal serum vitamin B12 levels and in patients suffering from vitamin B12 deficiency. A linear correlation was found between the two measurements, suggesting that the serum vitamin B12 level is a governing factor in the urinary loss of vitamin B12. The contribution by this loss to the total loss of vitamin B12 from the body is small under normal circumstances but becomes quantitatively more important with the depletion of body stores.