Papers And Originals

Clinical and Laboratory Studies with Rubella Vaccines in Adults

Br Med J 1969; 1 doi: http://dx.doi.org/10.1136/bmj.1.5639.271 (Published 01 February 1969) Cite this as: Br Med J 1969;1:271
  1. J. A. Dudgeon,
  2. W. C. Marshall,
  3. Catherine S. Peckham,
  4. G. T. Hawkins

    Abstract

    Three live attenuated rubella vaccines were tested in adult volunteers. Clinical reactions were mild, but were more noticeable in vaccinated non-immune subjects than in control subjects. With the exception of two individuals, all of the remaining 54 subjects developed an immune response; the level of antibodies found was somewhat lower than that resulting from natural infection. Though virus could be isolated from some of the seronegative volunteers after vaccination, no evidence was found of transmission of infection.

    Footnotes

    • * This work was carried out under the auspices of the Medical Research Council's Subcommittee on Rubella Vaccines.