Open clinical trials
BMJ 2012; 345 doi: https://doi.org/10.1136/bmj.e4749 (Published 18 July 2012) Cite this as: BMJ 2012;345:e4749- Philip Sedgwick, senior lecturer in medical statistics
- 1Centre for Medical and Healthcare Education, St George’s, University of London, Tooting, London, UK
- p.sedgwick{at}sgul.ac.uk
Researchers assessed the effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy. An open randomised controlled trial was performed. Control treatment consisted of watchful waiting. In total, 300 children aged 2-8 years were recruited and randomised to adenotonsillectomy (n=151) or control (n=149).1
The main outcome measures included episodes of fever, throat infections, upper respiratory tract infections, and health related quality of life. The researchers reported that adenotonsillectomy had no major clinical benefits over watchful waiting in children with mild symptoms of throat infections or adenotonsillar hypertrophy.
Which of the following types of bias, …
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