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RESEARCH: Durrane Thaver, Anita K M Zaidi, Julia Critchley, Asma Azmatullah, Syed Ali Madni, and Zulfiqar A Bhutta A comparison of fluoroquinolones versus other antibiotics for treating enteric fever: meta-analysis BMJ 2009; 338: b1865 [Abstract] [Full text]

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Side effect profile of Fluoroquinolones

Matiram Pun   (7 June 2009)

Side effect profile of Fluoroquinolones 7 June 2009
Matiram Pun, MDSC Grad Student University of Calgary, Health Sciences Center, Calgary, Alberta, T2N 4N1, Canada Send response to journal: Re: Side effect profile of Fluoroquinolones	Dear Editor, The meta-analysis by Durrane et al (1) on the use of fluoroquinolone antibiotics vs other antibiotics has included many trials though there are trials with lack of rigorous methodological criteria. Despite that, neither the analysis nor the editorial on the enteric fever treatment (2)have highlighted the adverse outcome of fluoroquinolones. The musculoskeletal injury especially tendinopathy (Achilles tendon and others) (3) has to be considered and adequately highlighted in such meta- analyses. Thank you! Dr Matiram Pun, Mountain Medicine and High Altitude Physiology, Health Sciences Centre, University of Calgary, Calgary, Alberta Canada References: (1). Thaver D, Zaidi AKM, Critchley J, Azmatullah A, Madni SA, Bhutta ZA. A comparison of fluoroquinolones versus other antibiotics for treating enteric fever: meta-analysis. BMJ 2009;338:b1865 (2). Parry, C. M, Beeching, N. J . Treatment of enteric fever 2009. BMJ 338: b1159-b1159 (3). Khaliq Y, Zhanel GG. Musculoskeletal injury associated with fluoroquinolone antibiotics. Clin Plast Surg. 2005 Oct;32(4):495-502 Competing interests: None declared