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PAPERS: Maureen T M Franssen, Johanna C Korevaar, Nico J Leschot, Patrick M M Bossuyt, Alida C Knegt, Klasien B J Gerssen-Schoorl, Cokkie H Wouters, Kerstin B M Hansson, Ron Hochstenbach, Kamlesh Madan, Fulco van der Veen, and Mariette Goddijn Selective chromosome analysis in couples with two or more miscarriages: case-control study BMJ 2005; 331: 137-141 [Abstract] [Full text]

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An Alternative Therapy

Jonathon Weber   (21 July 2005)

An Alternative Therapy 21 July 2005
Jonathon Weber, Undergraduate Student (Genetics) 53705 Send response to journal: Re: An Alternative Therapy	As a student in genetics, I would like to thank the authors of this paper for this analysis: that the correlation of maternal age, family history as well as having suffered two or more miscarriages being an indication for a couple to be carriers of chromosomal abnormalities. Was transvaginal sonography the method by which all of the females were clinically diagnosed for complete miscarriages? Pre-implantation genetic testing is an alternative therapy that can be used for couples that have had two or more miscarriages. This way the 0.5% to 10.2% chance of having a chromosome abnormality could be lowered including the risk of having a child with Tuner syndrome, Down syndrome, trisomy 18 and 13. However, would instigating pre-implantation genetic testing for all couples who have had two or more miscarriages going to help drive down the cost of medical care? Competing interests: None declared