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How to find no MMR link -exclude all cases from the study
- Clifford G. Miller (14 May 2005)
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Andrew Wakefield never suggested that MMR might be linked to Crohn's disease
- John Stone (14 May 2005)
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Competing interest
- John Stone (20 May 2005)
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Clifford G. Miller, Lawyer, graduate physicist, former university examining lecturer in law BR3 3LA
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Dear Sir, HOW TO FIND NO MMR LINK - EXCLUDE ALL CASES FROM THE STUDY Regrettably, this study "MMR vaccine and Crohn's disease: ecological study of hospital admissions in England, 1991 to 2002" [1] like some others seeking to cast doubt on the causal link between MMR, autism and related disorders seems self-confounding based on a deeply flawed method and possibly limited understanding of the subject-matter under study. The author, Valerie Seagroatt, statistician states:- "I restricted the
analysis to emergency admissions as these were probably less
susceptible to changes in thresholds for admission and clinical
practice than elective admissions."
This method pretty much guarantees that data relating to any ASD child, including PDD diagnosed child with Crohn's disease was not included in the study. The likelihood of anything for any of these children being diagnosed during an emergency admission is less than that of a somewhat small snowflake in a somewhat much larger hell fire. It can take four people to hold some of these children down just to take a blood test. The one problem parents of these children have had is that they have not been able to get proper diagnoses of their childrens' ailments. The failure of paediatric medicine and the NHS in this context is a common cause of complaint. Many complain they can get no treatment of any kind from the NHS for their children and that is particularly for those children with the most distressing disintegrative disorders. In the circumstances the statement that emergency admissions 'were probably less susceptible to changes in thresholds for admission and clinical practice' has to be questioned. On what science is such an assumption based? Where are the references. How was this assumption validated? Most importantly, why was this assumption made in the first place when anyone familiar with the issues over MMR caused autism-like and other conditions would know immediately it was invalid. This new paper is a good example of why it is necessary to be wary of people stepping outside their usual areas of expertise to hold forth on topics which may not be as close to their fields as might be desirable. This paper is also an example of why 'peer review' is of extremely limited value. In fact 'peer review' only occurs after publication and in other disciplines the process is referred to as refereeing and not peer reviewing. 1] MMR vaccine and Crohn's disease: ecological study of hospital admissions in England, 1991 to 2002 Valerie Seagroatt, statistician1 Unit
of Health-Care Epidemiology, Department of Public Health, University of
Oxford, Oxford OX3 7LF
Competing interests: None declared |
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John Stone, none London N22
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This paper does not relate to Andrew Wakefield's hypothesis that MMR is linked to a new kind of inflammatory bowel disease. Valerie Seagroatt's study would seem to refute a claim which has never been made. Competing interests: Parent of an autistic child |
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John Stone, none London N22
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The funding of Valerie Seagroatt's department by the Department of Health, although mentioned, should surely be listed as a competing interest. Competing interests: Parent of an autistic child |
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