Rapid Responses to:
|
|
Rapid Responses: Rapid Responses published:
-
![[Read Rapid Response]](/icons/misc/sectionDOWN.gif)
Progressive androgenisation of women
- Prof. Nikola Ilankovic, M.D.,Ph.D., Andrej N. Ilankovic,M.D.,M.Sc, Lana Marija Ilankovic (2 May 2005)
-
Human papilloma virus, sexual behaviour and logical places of infection and malignancy
- Nikola N Ilankovic (20 August 2009)
|
|
|||
|
Prof. Nikola Ilankovic, M.D.,Ph.D., Professor, Head University Clinical Center,YU-11000 BELGRADE, Pasterova 2, Andrej N. Ilankovic,M.D.,M.Sc, Lana Marija Ilankovic
Send response to journal:
|
Our hypothesis: 1. The increase of androgen levels (and other steroids, too) in women during life (and through generations) lead to masculinisation of women and problems with sexual behavior, gender identity and fertility. 2. Chronic stress, hard physical work, extreme physical exercise, hormone therapy, contraceptives, inborn and acquired endocrine disorders, some supplements in food (hormones in milk, meat), nicotinismus, alcohol and drug addiction, medication (corticosteroids, neuroleptics) - are some of many constitutional and environmental factors, which contribute to an increase of androgen and steroid levels in women and accelerate the process of androgenisation (masculinisation). In cycling infertile women, increasing BMI (body mass index) and cigarette smoking are associated with increased serum testosterone. (1) 3. During pregnancy (pregnancies) these women develop a prenatal, transplacental, masculinisation of feminine fetus (masculinisation of girls), due to high level of androgens and other steroids (cortisol) in circulation of the mother. (2) On other side, the high level of androgens and other steroids by mother develop a prenatal, transplacental, underandrogenisation of masculine fetus (feminization of boys) due to suppression of hypophyseal hormones (negative feedback). 4. This phenomena will be accelerated: a) with every pregnancies during life in each woman, b) in late life pregnancies (pregnancies in 4th and 5th decade of life), c) through next generations, and d) through different environmental influences (physical, chemical, psychosocial). 5. The consequences of these hormonal changes or disturbances (“PROGRESSIVE ANDROGENISATION” through more generations) are: a) Masculinisation of women,
6. The process of progressive androgenisation in women results through generations in transformation of biological and psychological gender identity, and finally, in infertility. (5) 7. The biological, chemical and psychosocial factors in environment accelerate this evolutionary process of natural selection in species of homo sapiens (and perhaps in some other species, too). (6) References: 1. Barbieri RL, Sluss PM, Powers RD, McShane PM, Vitonis A, Ginsburg E, Cramer DC. Association of body mass index, age, and cigarette smoking with serum testosterone levels in cycling women undergoing in vitro fertilization. : Fertil Steril. 2005 Feb;83(2):302-8. 2. Allison A. Baileya, Peter L. Hurda, Finger length ratio (2D:4D) correlates with physical aggression in men but not in women. Biological Psychology 2005, 68:215-222 3. Sundquist, K., Frank, G, & Sundquist, J. (2004) Urbanisation and incidence of psychosis and depression. Follow-up study of 4,4 million women and men in Sweden. British Journal of Psychiatry, 184, 293-298. 4. Howard, J. (2004) Testosterone and psychosis. British Journal of Psychiatry, 185:173. 5. Howard, J. (2001) Androgens in human evolution. A new explanation in human evolution. Rivista di Biologia, 94, 345-362. 6. Howard, J. (2001) Hormones in mammalian evolution. Rivista di Biologia, 94, 177-183. Competing interests: None declared |
|||
|
|
|||
|
Nikola N Ilankovic, Professor, Head University Clinical Center, Belgrade, 11000
Send response to journal:
|
The locations on the body of sexual transmitted infections with human papilloma viruses, can correlate with "inovationes" in sexual behaviour. It is logical that the viral affects (condilomata, precancerous lesions and carcinoma) can be located on cervix, vulva, glans penis, prostata, anal region, oral region and tongue, head and neck, larynx, oesophagus and breast. Very important is the possible causal connection between human papilloma virus infection and breast carcinoma. Data show that apart from the heart and the kidney, the virus has been found in all other organs that have been analyzed so far, i.e., prostate, urinary bladder, oral cavity, larynx, esophagus, stomach, colon, liver, vagina/vulva, endometrium, ovary, breast, penis, anus, skin, and lung. Some of the detection rates are remarkable, e.g., colon cancer up to 97%, lung cancer 80%, and breast cancer 74% (Petersen I, Klein F., 2008)*. Double primary carcinomas (cervix and breast) in the same person is not rare.** The occurrence of a second malignancy in a patient with a known malignant tumor is not uncommon. It could be supposed the same or similar etiology (Viral?, HPV ??***) or coincidence of different etiological factors. Maybe the new antiviral therapy and the Gardasil vaccination can be helpful for different types of malignancy, especially for very frequent and dangerous breast, anal and ovarian cancers. * Pathologe. 2008 Nov;29 Suppl 2:118-22. ** http://www.google.com/search?q=double+carcinoma+cervix+breast&rls=com.microsoft:en -us:IE-SearchBox&ie=UTF-8&oe=UTF-8&sourceid=ie7&rlz=1I7ADBS ***British Journal of Cancer (2006) 94, 338–338. ***Breast Cancer Research and Treatment (1992), Vol.21, No 2 Competing interests: None declared |
|||