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OBITUARIES: Denis Pereira Gray Robert Edgar Hope-Simpson BMJ 2003; 327: 1111 [Full text]

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Dormant flu.

Friedrich Flachsbart   (8 November 2003)

Innate immunity of silent picorna infection.

Friedrich Flachsbart   (10 November 2003)

Edgar Hope-Simpson as a Beaminster GP

Oliver R Dearlove, Dr John Dearlove   (16 November 2003)

The Channel is Essential for Innate Immunity.

Friedrich Flachsbart   (4 March 2004)

Dormant flu. 8 November 2003
Friedrich Flachsbart, General medicine 37085 Göttingen Send response to journal: Re: Dormant flu.	Dear Sir, every year we see the wave of common cold rolling. We should think about a sleeping life-long infection of common cold virus, streptococcus and phages. Silenced RNA becomes activated by cold wind and low sun-radiation- intensity. RNA-virus activates dormant commensuals like streptococci, phages induce virulence-gene-factor expression. Secondary pathogen-exchange from man to man is following. And post-streptococcal-reactive-diseases emerge. This would be another view on flu. Sincerily Yours Friedrich Flachsbart Competing interests: None declared
Innate immunity of silent picorna infection. 10 November 2003
Friedrich Flachsbart, General medicine 37085 Göttingen Send response to journal: Re: Innate immunity of silent picorna infection.	Dear Sir, like Hanta and Hepatitis C a persistent picorna infection seems possible. The Genome's Immune System holds them under control by a number of steps of small RNA processes. Receptor mutations like CCR5 delta 32 help to survive in the cold. Ion-channel mutations like CF and asthma help to survive. Serine-Proteases-Inhibitors mutations help to survive. We only have to look into old diseases with new ideas and methods to promote medicine. Sincerily Yours Friedrich Flachsbart Competing interests: None declared
Edgar Hope-Simpson as a Beaminster GP 16 November 2003
Oliver R Dearlove, Consultant Anaesthetist Royal Manchester Children's Hospital, M27 4HA, Dr John Dearlove Send response to journal: Re: Edgar Hope-Simpson as a Beaminster GP	Until Dr Hope Simpson died, I only knew of him as my late father's predecessor in general practice, in Beaminster, West Dorset until 1945. The senior partner in the practice was Dr Herbert Lake. This side of Dr Hope Simpson's life is not covered at all in his BMJ obituary. Further information can be accessed on, http://www.drherbertlake.org.uk/edgar.htm, which is maintained by my brother Dr John Dearlove. Competing interests: None declared
The Channel is Essential for Innate Immunity. 4 March 2004
Friedrich Flachsbart, General Medicine Praxis 37085 Göttingen Send response to journal: Re: The Channel is Essential for Innate Immunity.	Dear Sir, neutrophil leukocytes kill microbes by proteases. Large-conductance Ca-activated K channels are essential in this process. J. Ahluwalia et al.: The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature 2004;427:853-858 Sincerily Yours Friedrich Flachsbart Competing interests: None declared