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Beyond C Reactive Protein: "biophysical-semeiotic arteriosclerotic constitution".

Sergio Stagnaro   (30 August 2002)

Beyond C Reactive Protein: "biophysical-semeiotic arteriosclerotic constitution". 30 August 2002
Sergio Stagnaro, Specialist in Blood, Gastrointestinal, and Metabolic Diseases Via Erasmo Piaggio 23/8 16037 Riva Trigoso (Genoa) Italy Send response to journal: Re: Beyond C Reactive Protein: "biophysical-semeiotic arteriosclerotic constitution".	Sirs, in my opinion (as illustrated in details in my site HONCode, N°233736, http://digilander.libero.it/semeioticabiofisica, Practical Applications: Acute Phase Proteins) the problem, concerning the relation beween C Reactive Protein and coronary artery disease, is a long way from being resolved by such reductive and inconclusive arguments, as those, referred to in the paper, and which will probably be published next in a great peer review. To summarize, the liver production of APP, and obviously of CRP, is clearly altered and more intense in healthy individuals, affected, however, since birth, by “arteriosclerotic biophysical-semeiotic constitution”, fully described in above-cited site (“Biophysical-Semeiotics Constitutions”). I can’t agree, moreover, with Christopher O’Donnell’s apparently compelling assertion, when referring to data on CRP blood concentration, gathered in 327 people (mean age 60) with different CRP blood level: “These were healthy, free-living individuals largely free of antibiotic use. They had no clinical evidence of infection,” ...” Patients with higher concentrations of C reactive protein in the earlier test had higher calcification scores, indicating that they were at higher risk for cardiovascular events”. In fact, as allows me to state a 45-year-long “clinical” experience with the aid of an original physical semeiotics (1, 2, 3), we can find calcification in whatever tissue or biological system “only” in individuals affected by an inherited dysfunction, metabolic-endocrine in origin, which I termed “variant” Reaven’s syndrome, conditio sine qua non of arterial calcifications, gallbladder and kidney-stones, and “all” other calcium deposits (4, 5) (For further information, See my above-cited site, Practical Application). In conclusion, although ignored or overlooked by almost all authors around the world, biophysical-semeiotic constituions do exist “really”: diabetic, dyslipidaemic, hypertensive, arteriosclerotic, glaucomatous, oncological, a.s.o.,constitution, which could allow us, to perform an efficacious “primary” prevention of most common and dangerous human diseases, on very large scale, i.e., clinically. Despite the large number of conservative physicians as well as conservative peer reviews, scientific progresses go on , unfortunately slowly, but go on. Sergio Stagnaro MD., Member NYAS 1) Stagnaro S. Rivalutazione e nuovi sviluppi di un fondamentale metodo diagnostico: la percussione ascoltata. Atti Accademia Ligure di Scienze e Lettere. Vol. XXXIV, 1978. 2) Stagnaro S., Stagnaro-Neri M. Percussione Ascoltata della Sindrome Ferro-Carenziale. Med. Praxis 17, 4, 1, 1986. 3) Stagnaro-Neri M., Stagnaro S., Il segno di Daneri. Gazz. Med. It. – Arch. Sc. Med. 147, 215, 1986 (Pub-Med). 4) Stagnaro-Neri M., Stagnaro S., La "Costituzione Colelitiasica":ICAEM-a, Sindrome di Reaven variante e Ipotonia-Ipocinesia delle vie biliari. Atti. XII Settim. It. Dietol. Merano, ottobre 1992 ed Epatol. 20, 239, 1993. 20, 239, 1993. 5) Stagnaro S.-Neri M., Stagnaro S., Sindrome di Reaven, classica e variante, in evoluzione diabetica. Il ruolo della Carnitina nella prevenzione del diabete mellito. Il Cuore. 6, 617 (Pub-Med indexed for Medline), 1993.