BMJ, doi: 10.1136/bmj.39570.393218.BE, (Published 21 May 2008)

Editorials

Assessing patients’ improvement in clinical trials

Should the doctor or patient judge improvement, and does it matter?

The first 150 words of the full text of this article appear below.

Doctors need to understand the benefits of new treatments from patients’ perspectives, because they must judge the relative risks and benefits of offering such treatments to patients. The field of health status assessment has evolved to meet this need, and several patient completed instruments have been developed that are valid, reliable, and sensitive to treatment.1 Such tools can provide invaluable insights into how a treatment affects outcomes such as function and quality of life, which can be more important to patients than survival.2 3 4 For some conditions, however, measures of disease specific health status are not available, and global assessments of clinical change are used.

Although valid approaches are available for measuring global change experienced by patients,5 6 simple ad hoc measures are often used and can be assessed from the perspective of the patient or the doctor. In the accompanying survey of trials included in systematic reviews, Evangelou and colleagues determine . . . [Full text of this article]

John Spertus, professor, University of Missouri

1 Mid America Heart Institute, Kansas City, MO 64111, USA

spertusj@umkc.edu


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Relevant Article

Doctors’ versus patients’ global assessments of treatment effectiveness: empirical survey of diverse treatments in clinical trials
Evangelos Evangelou, Georgios Tsianos, and John P A Ioannidis
BMJ 2008 336: 1287-1290. [Abstract] [Full Text] [PDF]

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