BMJ, doi: 10.1136/bmj.39517.508241.80, (Published 18 March 2008)

Editorials

Renal complications of childhood type 1 diabetes

Are correlated with glycated haemaglobin, so tight control is needed from the start

The first 150 words of the full text of this article appear below.

The primary goal of managing childhood type 1 diabetes is to prevent or delay retinal and renal microvascular complications. Because lesions are silent for a long time,¹ glycated haemoglobin (HbA_1c) concentrations are used as a surrogate measure of the adequacy of treatment to avoid diabetic complications. Most of our knowledge of the relation between control of diabetes and the risk of renal complications of diabetes comes from data in adults and adolescents, so it is important to have a precise evaluation of the risk in children.

In the accompanying paper, Amin and colleagues report on the risk of diabetic renal disease in the Oxford regional prospective study, a population based cohort study of children with type 1 diabetes.² The prevalence of microalbuminuria was about 25% and 50% after 10 and 20 years of diabetes, respectively. The natural course of microalbuminuria was such that about half of patients reverted at . . . [Full text of this article]

¹ Department of Paediatric Endocrinology and Diabetology, INSERM U690, Robert Debré Hospital 75019 Paris, France and University Paris 7 Denis Diderot, 75010 Paris, France

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Articles

Risk of microalbuminuria and progression to macroalbuminuria in a cohort with childhood onset type 1 diabetes: prospective observational study

Rakesh Amin, Barry Widmer, A Toby Prevost, Phillip Schwarze, Jason Cooper, Julie Edge, Loredana Marcovecchio, Andrew Neil, R Neil Dalton, and David B Dunger
BMJ 2008 336: 697-701. [Abstract] [Full Text] [PDF]

Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review

Giovanni F M Strippoli, Maria Craig, Jonathan J Deeks, Francesco Paolo Schena, and Jonathan C Craig
BMJ 2004 329: 828. [Abstract] [Full Text] [PDF]

Rapid Responses:

Read all Rapid Responses

Young people are given no chance to have normal blood sugars to reduce renal and other complications of diabetes

Katharine Morrison
bmj.com, 1 Apr 2008 [Full text]