BMJ, doi: 10.1136/bmj.39497.622720.80, (Published 29 February 2008)

Editorials

Managing uninvestigated dyspepsia in primary care

Test and treat for Helicobacter pylori is still as good as proton pump inhibitors first

The first 150 words of the full text of this article appear below.

In their accompanying paper, Delaney and colleagues report a randomised controlled trial of 699 people with uninvestigated dyspepsia, which compares the strategy of "test and treat" for Helicobacter pylori infection against empirical acid suppression using a proton pump inhibitor.¹ The test and treat group was tested for H pylori infection and positive patients were given eradication treatment, whereas negative patients were given proton pump inhibitors. Previous studies have looked at people who were H pylori positive² or H pylori negative,³ but none has used test and treat as an overall strategy—instead, if patients were H pyloripositive they were randomised to eradication treatment or placebo; if they were negative they were randomised to proton pump inhibitors, other drugs, or placebo.

Dyspepsia is a common symptom complex of epigastric pain or discomfort—which includes symptoms of heartburn, acid regurgitation, excessive belching, increased abdominal bloating, nausea, feeling of abnormal or slow digestion, or . . . [Full text of this article]

¹ McMaster University, Hamilton, ON, Canada, L8S4L8

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Articles

Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial)

Brendan C Delaney, Michelle Qume, Paul Moayyedi, Richard F A Logan, Alexander C Ford, Cathy Elliott, Cliodna McNulty, Sue Wilson, and F D Richard Hobbs
BMJ 2008 336: 651-654. [Abstract] [Full Text] [PDF]

Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatmentHelicobacter pylori positive (CADET-Hp) randomised controlled trial

Naoki Chiba, Sander J O Veldhuyzen van Zanten, Paul Sinclair, Ralph A Ferguson, Sergio Escobedo, and Eileen Grace
BMJ 2002 324: 1012. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

• (2008). Test-and-Treat for H. pylori vs. Acid Suppression for Dyspepsia. JWatch General 2008: 5-5 [Full text]