Breast cancer mortality in Copenhagen after introduction of mammography screening: cohort study

doi:10.1136/bmj.38313.639236.82

BMJ, doi: 10.1136/bmj.38313.639236.82, (Published 13 January 2005)

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Breast cancer mortality in Copenhagen after introduction of mammography screening: cohort study

Anne Helene Olsen ¹, Sisse H Njor ¹, Ilse Vejborg ², Walter Schwartz ³, Peter Dalgaard ¹, Maj-Britt Jensen ², Ulla Brix Tange ², Mogens Blichert-Toft ², Fritz Rank ², Henning Mouridsen ², Elsebeth Lynge ¹

¹ Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark
² University Hospital Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen $Ø$ , Denmark
³ Mammography Screening Clinic, University Hospital Odense, Kløvervænget 10, DK-5000 Odense, Denmark

Objectives To evaluate the effect on breast cancer mortalityduring the first 10 years of the mammography service screeningprogramme that was introduced in Copenhagen in 1991.

Design Cohortstudy.

Setting The mammography service screening programme inCopenhagen, Denmark.

Participants All women ever invited to mammographyscreening in the first 10 years of the programme. Historical,national, and historical national control groups were used.

Mainoutcome measures The main outcome measure was breast cancermortality. We compared breast cancer mortality in the studygroup with rates in the control groups, adjusting for age, timeperiod, and region.

Results Breast cancer mortality in the screeningperiod was reduced by 25% (relative risk 0.75, 95% confidenceinterval 0.63 to 0.89) compared with what we would expect inthe absence of screening. For women actually participating inscreening, breast cancer mortality was reduced by 37%.

ConclusionsIn the Copenhagen programme, breast cancer mortality was reducedwithout severe negative side effects for the participants.

(Accepted 15 November 2004)

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