Non-specific effects of vaccination on child survival: prospective cohort study in Burkina Faso

doi:10.1136/bmj.38261.496366.82

BMJ, doi: 10.1136/bmj.38261.496366.82, (Published 18 November 2004)

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Non-specific effects of vaccination on child survival: prospective cohort study in Burkina Faso

J Vaugelade ¹, S Pinchinat ², G Guiella ³, E Elguero ¹, F Simondon ¹

¹ Institut de Recherche pour le Développement, Laboratoire Population, Environnement et Développement, BP 64501, 34394 Montpellier Cedex 5, France
² Biostatem, Parc Scientifique G Besse, F 30035 Nîmes, France
³ Unité d'Etudes et de Recherche en Démographie, 03 BP 7118, Ouagadougou 03, Burkina Faso

Objective To study the effect of vaccination on mortality before2 years of age in a developing country.

Design Prospective cohortstudy.

Setting Rural communities in Burkina Faso.

Participants9085 children born in the study area between 1985 and 1993.

Mainoutcome measure Child death rate.

Results Mortality before 2years of age was lower in children who had been vaccinated:those vaccinated with BCG only had significantly lower mortality(risk ratio for vaccinated v unvaccinated children 0.37, 95%confidence interval 0.29 to 0.48) as did those vaccinated withdiphtheria, tetanus, and pertussis only (0.24, 0.13 to 0.43).The second dose of diphtheria, tetanus, and pertussis was notassociated with lower mortality (0.80, 0.58 to 1.12).

ConclusionVaccination with diphtheria, tetanus, and pertussis as wellas BCG is associated with better survival of children up to2 years of age.

(Accepted 25 September 2004)

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