Research pointers: Risk of subsequent thromboembolism for patients with pre-eclampsia

doi:10.1136/bmj.326.7393.791

BMJ 2003;326:791-792 ( 12 April )

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Research pointers

Risk of subsequent thromboembolism for patients with pre-eclampsia

Carl van Walraven, scientist ^a, Muhammad Mamdani, scientist ^b, Adam Cohn, resident ^c, Yasir Katib, resident ^c, Mark Walker, associate scientist ^a, Marc A Rodger, associate scientist ^a.

^a Thrombosis of placental vessels causes pre-eclampsia. Women with pre-eclampsia had an increased risk of subsequent venous thromboembolism Ottawa Health Research Institute, Ottawa, Canada K1Y 4E9, ^b Institute for Clinical Evaluative Sciences, Toronto, Canada M4N 3N5, ^c University of Ottawa, Ottawa, Canada K1H 8M5

Correspondence to: C van Walraven carlv@ohri.ca

The first 150 words of the full text of this article appear below.

Inherited thrombophilias affect over 16% of people and predispose them to venous thromboembolism.¹ Pre-eclampsia is associatedwith occlusion of the placental spiral arteries.² Thrombophiliasmay cause thrombosis of placental vessels,³ thereby explainingthe link between thrombophilia and pre-eclampsia. ⁴ ⁵ We testedthe hypothesis that women with pre-eclampsia have a higher riskof subsequent venousthromboembolism.

Participants, methods, and results

The study was approved by our research ethics board and took place in Ontario, Canada, where all hospital services are publiclyfunded. We used an administrative database that is based on anonymisedpopulations and which records all hospitalisations from 1 April1988 onwards. All discharges between 1 April 1990 and 1 January1994 with a primary ICD-9 (international classification of diseases,9th revision) code of pre-eclampsia, severe pre-eclampsia, eclampsia,or toxaemia were identified (see appendix A on bmj.com). Thesecodes had a sensitivity of 89% (95% confidence interval 78% to94%) and a specificity of 67% (79% to 94%) for patients with . . . [Full text of this article]

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Risk of subsequent thromboembolism for patients with pre-eclampsia
BMJ 2003 326: 1362. [Full Text] [PDF]

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