Rising incidence of Kawasaki disease in England: analysis of hospital admission data

doi:10.1136/bmj.324.7351.1424

BMJ 2002;324:1424-1425 ( 15 June )

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Rising incidence of Kawasaki disease in England: analysis of hospital admission data

Anthony Harnden, university lecturer ^a, Bernadette Alves, health services researcher ^b, Aziz Sheikh, NHS research and development national primary care training fellow ^b.

^a Department of Primary Health Care, Institute of Health Sciences, University of Oxford, Oxford OX3 7LF, ^b Department of Primary Health Care, Imperial College of Science, Technology and Medicine, London W2 1PG

Correspondence to: A Harnden anthony.harnden@dphpc.ox.ac.uk

The first 150 words of the full text of this article appear below.

Kawasaki disease is the leading cause of acquired heart disease in children in the developed world and may be a risk factorfor adult ischaemic heart disease.¹ A fifth of untreated childrendevelop cardiac lesions during the acute phase of the disease.The cause remains uncertain. Epidemiological studies support aninfectious agent inducing the disease in a genetically susceptibleminority. Superantigen toxins have been implicated. Reported incidencerates differ considerably throughout the developed world withrates in Japan 10 times those in the United States and 30 timesthose in the United Kingdom and Australia.^2-4 Hospital surveillancedata suggest the incidence of Kawasaki disease in Japan has risenby over 50% between 1987 and 1998.² To ascertain whether therehad been a similar rise in England, we investigated trends inhospital admissions for Kawasaki disease using routinely collectedstatistics from 1991 to2000.

Methods and results

The hospital episode statistics database provides information on every inpatient admission . . . [Full text of this article]

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