Risk of HIV related Kaposi's sarcoma and non-Hodgkin's lymphoma with potent antiretroviral therapy: prospective cohort study

BMJ 1999;319:23-24 ( 3 July )

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Risk of HIV related Kaposi's sarcoma and non-Hodgkin's lymphoma with potent antiretroviral therapy: prospective cohort study

Bruno Ledergerber, senior research fellow ^a, Amalio Telenti, clinical reader in infectious diseases ^b, Matthias Egger, senior lecturer in epidemiology and public health medicine ^c, for the Swiss HIV Cohort Study.

^a Division of Infectious Diseases, Department of Medicine, University Hospital Zurich, CH-8091 Zurich, Switzerland, ^b Division of Infectious Diseases, Department of Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland, ^c MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol BS8 2PR

Correspondence to: Dr Egger m.egger@bristol.ac.uk

The first 150 words of the full text of this article appear below.

The rate of progression to new AIDS defining events has been reduced considerably since the introduction of potent antiretroviralcombination therapy. ¹ ² It is unclear, however, whether thereduction has been the same for all opportunistic infections andmalignancies, or whether the effect has been greater for someconditions than for others. We examined this question in the SwissHIV Cohort Study, a large community cohort of adults with HIVinfection.

Participants, methods, and results

The study methods are described in detail elsewhere. ¹ ³ The cohort includes the majority of people with advanced HIVinfection in Switzerland. Potent antiretroviral combination therapy(triple combinations including at least one protease inhibitor)was gradually introduced from 1995 onwards. By mid-1997, 70% ofpatients with a history of CD4 cell counts below 200 × 10⁶/l were receiving thistreatment.

The incidence of all new AIDS conditions fell from 157 events (95% confidence interval 148 to 166) per 1000 person-years in1992 to 1994 (before combination therapy) to . . . [Full text of this article]

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