BMJ 1997;315:1283 (15 November)

Papers

Omeprazole, H2 blockers, and polyarthralgia: case-control study

Christoph R Meier, research associate,a Hershel Jick, associate professor of medicine a

a Boston Collaborative Drug Surveillance Program, Boston University Medical Center, 11 Muzzey Street, Lexington, MA, 02173, USA

Correspondence to: Dr Meier chrmeier@bu,edu


right arrow   Introduction

Acute polyarthralgia has been reported in five patients in association with the proton pump inhibitor omeprazole.1 These patients did not have rheumatoid arthritis, concurrent infections, or connective tissue disorders, and their symptoms resolved after stopping omeprazole.1 We compared the relative risk of developing acute idiopathic polyarthralgia during and after exposure to omeprazole, ranitidine, or cimetidine, antiulcer drugs used for similar indications.


right arrow   Subjects, methods, and results

We conducted a nested case-control analysis using data from a UK general practitioner research database which provides the demographics, medical conditions, and drug prescriptions of over four million people.2 3 4

Cohort members comprised people aged 20-60 who had received at least one prescription for omeprazole, ranitidine, or cimetidine between 1 January 1992 and 31 December 1994 and had at least one year's medical history recorded on computer. Subjects were excluded if they had a history of idiopathic multiple arthralgia or . . . [Full text of this article]


right arrow   Comment

right arrow   Acknowledgements

right arrow   References

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to StumbleUpon StumbleUpon   Add to Technorati Technorati    What's this?

This article has been cited by other articles:

  • Green, M. J, Iveson, M., Crook, R., Burrows, N., Gough, A. K. (2002). Careless talk may cost lives in attributing adverse events to ADP receptor antagonists. BMJ 324: 1039-1039 [Full text]  
Access jobs at BMJ Careers
Whats new online at Student BMJ