Omeprazole, H2 blockers, and polyarthralgia: case-control study

BMJ 1997;315:1283 (15 November)

Papers

Omeprazole, H2 blockers, and polyarthralgia: case-control study

Christoph R Meier, research associate,^a Hershel Jick, associate professor of medicine ^a

^a Boston Collaborative Drug Surveillance Program, Boston University Medical Center, 11 Muzzey Street, Lexington, MA, 02173, USA

Correspondence to: Dr Meier chrmeier@bu,edu

Introduction

Acute polyarthralgia has been reported in five patients in associationwith the proton pump inhibitor omeprazole.¹ These patients didnot have rheumatoid arthritis, concurrent infections, or connectivetissue disorders, and their symptoms resolved after stoppingomeprazole.¹ We compared the relative risk of developing acuteidiopathic polyarthralgia during and after exposure to omeprazole,ranitidine, or cimetidine, antiulcer drugs used for similarindications.

Subjects, methods, and results

We conducted a nested case-control analysis using data froma UK general practitioner research database which provides thedemographics, medical conditions, and drug prescriptions of overfour million people.² ³ ⁴

Cohort members comprised people aged 20-60 who had receivedat least one prescription for omeprazole, ranitidine, or cimetidinebetween 1 January 1992 and 31 December 1994 and had at leastone year's medical history recorded on computer. Subjects were excludedif they had a history of idiopathic multiple arthralgia or . . . [Full text of this article]

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