BMJ  2006;333 (18 November), doi:10.1136/bmj.333.7577.0-b

This week in the BMJ

Baseline serum albumin concentrations do not affect resuscitation outcomes

Fluid resuscitation with saline or albumin produces similar outcomes regardless of patients' baseline serum albumin concentrations say the SAFE study investigators in their randomised controlled trial of 6045 patients across 16 intensive care units (doi: 10.1136/bmj.38985.398704.7C). They randomised 2451 patients with baseline albumin concentrations of 25 g/l or less and 3594 with values greater than 25 g/l to receive either saline or albumin during resuscitation. Rates of admission to intensive care and renal replacement therapy, and length of mechanical ventilation and hospital stay did not differ between groups.

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Relevant Article

Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study

SAFE Study Investigators
BMJ 2006 333: 1044. [Abstract] [Full Text] [PDF]

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