BMJ  2006;333 (7 October), doi:10.1136/bmj.333.7571.0-a

Combined antithrombotic therapy is risky

Combined antithrombotic drug treatment is associated with high incidence of serious upper gastrointestinal bleeding. Hallas and colleagues (p 726) matched 1443 cases of serious upper gastrointestinal bleeding with over 55 000 controls and looked at their exposure to antithrombotic agents alone or in combination. Adjusted odds ratios associating drug use with gastrointestinal bleeding were between 1 and 2 for low dose aspirin, clopidogrel, dipyridamole, and vitamin K antagonists alone. Corresponding figures for aspirin in combination with clopidogrel, vitamin K antagonists, or dipyridamole were 7.4, 5.3, and 2.3.

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Relevant Article

Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study

Jesper Hallas, Michael Dall, Alin Andries, Birthe Søgaard Andersen, Claus Aalykke, Jane Møller Hansen, Morten Andersen, and Annmarie Touborg Lassen
BMJ 2006 333: 726. [Abstract] [Full Text] [PDF]

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