BMJ  2006;333 (9 September), doi:10.1136/bmj.333.7567.0

Routine use of ibuprofen after hip replacement is not justified

Routine postoperative ibuprofen as prophylaxis for ectopic bone formation after hip replacement surgery has no significant clinical benefits 6 to 12 months after surgery. Fransen and colleagues (p 519) randomised 902 patients undergoing elective primary or revision total hip replacement surgery to 14 days' treatment with ibuprofen (1200 mg daily) or matching placebo started within 24 hours of surgery. Despite a decreased risk of ectopic bone formation, ibuprofen made no significant difference to improvements in hip pain or physical function. It did, however, increase the risk of major bleeding complications.

Credit: THE GEORGE INST/U OF SYDNEY

 

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