BMJ  2006;333 (12 August), doi:10.1136/bmj.333.7563.0-a

Metoclopramide helps reduce postoperative nausea and vomiting

Intraoperative administration of 50 mg metoclopramide, in addition to dexamethasone, is effective, safe, and cheap in preventing postoperative nausea and vomiting, say Wallenborn and colleagues on page 324. They randomised more than 3100 patients who had received anaesthesia for surgery to different doses of metoclopramide (0, 10, 25, or 50 mg) in addition to the recommended 8 mg dexamethasone. The cumulative incidence of nausea and vomiting decreased in a dose-related fashion with increasing metoclopramide, from 23.1% for dexamethasone alone to 14.5% for dexamethasone plus 50 mg metoclopramide.

Credit: ALIX/PHANIE/REX

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Relevant Article

Prevention of postoperative nausea and vomiting by metoclopramide combined with dexamethasone: randomised double blind multicentre trial

Jan Wallenborn, Götz Gelbrich, Detlef Bulst, Katrin Behrends, Hasso Wallenborn, Andrea Rohrbach, Uwe Krause, Thomas Kühnast, Martin Wiegel, and Derk Olthoff
BMJ 2006 333: 324. [Abstract] [Full Text] [PDF]