Table 1 Recommended antiretroviral dosing for children aged 2-12 years used in this analysis⁸

Committees and participants (alphabetical)

Table 1 Recommended antiretroviral dosing for children aged 2-12 years used in this analysis⁸

	Growth parameter	Minimum recommended daily dose8	Maximum daily dose prescribed (usually adult dose)	Weight / SA at which maximum dose reached	Median age of children in CHIPS at weight/SA for maximum dose (years)
NRTI
zidovudine	m2	360mg/m2	600mg	1.67m2	14.7
lamivudine	kg	8mg/kg	300mg	37.5kg	11.9
abacavir	kg	16mg/kg	600mg	37.5kg	11.9
didanosine	m2	180mg/m2 * 400mg if >60kg	400mg	2.22m2 60kg	16.8 15.0
stavudine	kg	2mg/kg 60mg if 30-60kg 80mg if >60kg	80mg	60kg	15.0
tenofovir	kg	6mg/kg	300mg	50kg	13.9
NNRTI
nevirapine	m2	300mg/m2 *	400mg	1.33m2	12.6
efavirenz	kg	12.5mg/kg †	600mg	48kg	13.2
PI
lopinavir /ritonavir	m2	460/115mg/m2 *‡	800/200mg	1.74m2	15.4
nelfinavir	kg	110mg/kg	2500mg	22.7kg	7.3
ritonavir	m2	700mg/m2	1200mg	1.71m2	15.1

* the lower limit of the range of doses included in guidelines

† approximate dose for weight, based on the more complex formula 600*(weight/70)^0.7 used in the original study¹¹. Higher doses are recommended for syrup (approx 15mg/kg), and licensed dosing is based on weight bands (corresponding to a wider range of doses per kilo): 13-<15kg 200mg, 15-<20kg 250mg, 20-<25kg 300mg, 25-<32.5kg 350mg, 32.5-40kg 400mg, >40kg 600mg. Formulation data are not collected in CHIPS.

‡ higher doses are recommended if taken concurrently with NNRTI.

Note: shaded boxes denote current best dose where approved paediatric dose has not yet been licensed. SA = surface area.

 

 

Committees and participants (alphabetical):

CHIPS Steering Committee: K Butler, K Doerholt, D Dunn, T Duong, D Gibb, H Lyall, J Masters, E Menson, V Novelli, C Peckham, A Riordan, M Sharland, P Tookey, G Tudor-Williams, G Wait

National Study of HIV in Pregnancy & Childhood, Institute of Child Health: Janet Masters, Catherine Peckham, Pat Tookey

MRC Clinical Trials Unit: D Dunn, T Duong, L Farrelly, D Gibb, D Johnson, E Menson, G Wait, AS Walker

We thank the staff, families & children from the CHIPS centres:

Republic of Ireland: Our Lady's Hospital for Sick Children, Dublin: K Butler, M O'Meara, A Walsh

UK: Heartlands Hospital, Birmingham: A Riordan; Bristol Royal Hospital for Children, Bristol: A Finn, A Foot, L Hutchison, Ninewells Hospital and Medical School, Dundee: T Lornie; Ealing Hospital, Middlesex: K Sloper, V Shah; Royal Edinburgh Hospital for Sick Children, Edinburgh: J Mok; Great Ormond St Hospital for Children, London: DM Gibb, V Novelli, N Klein, S Fasolo, M Clapson, B Ohene-Kena, J Flynn, K Moshal; King's College Hospital, London: C Ball, D Nayagam, S Hawkins; Newham General Hospital, London: S Liebeschuetz, E Cooper, D Shingadia, T Fisher, S Wong, Northampton General Hospital, Northhampton: F Thompson; Royal Free Hospital, London: V Van Someren, S McKenna; St George's Hospital, London: M Sharland, R Chakraborty, S Donaghy, S Storey, C Wells; St Mary's Hospital, London: G Tudor-Williams, H Lyall, S Walters, S Campbell, C Hanley, C Walsh; St Thomas' Hospital, London: G Du Mont, R Cross; University Hospital Lewisham, London: J Stroobant; John Radcliffe Hospital, Oxford: A Pollard, S Segal; Sheffield Children's Hospital, Sheffield: F Shackley, J Hobbs; Chelsea and Westminster Hospital, London: H Lyall, P Seery; North Middlesex Hospital, London: H Lyall, J Daniels, B Sampson-Davis; University Hospital of Wales, Cardiff: B O' Hare; Royal London Hospital, London: D Shingadia, B Ramaboea; Northwick Park Hospital, Middlesex: A Williams, M Le Provost; Central Middlesex Hospital, London: A Williams, M Le Provost; Wexham Park, Slough: R Jones

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