BMJ  2006;332 (1 April), doi:10.1136/bmj.332.7544.0-c

What are the risks for couples with a balanced structural chromosome abnormality?

Couples found to be carrying a balanced structural chromosomal abnormality after two or more miscarriages are at low risk of having a viable offspring with unbalanced chromosomal abnormalities (that is, with major congenital defects). In a case-control study of 278 carrier couples and 427 non-carrier couples who had had two or more miscarriages, Franssen and colleagues (p 759) looked at reproductive outcomes over at least 24 months. The carrier couples' chances of having a healthy child were as high as those of the non-carrier couples, but they had a higher risk of miscarriages.

Credit: ADDENBROOKES HOSPITAL/SPL

 

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Relevant Article

Reproductive outcome after chromosome analysis in couples with two or more miscarriages: case-control study

Maureen T M Franssen, Johanna C Korevaar, Fulco van der Veen, Nico J Leschot, Patrick M M Bossuyt, and Mariette Goddijn
BMJ 2006 332: 759-763. [Abstract] [Full Text] [PDF]

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