BMJ  2005;331:1041 (5 November), doi:10.1136/bmj.331.7524.1041

News

Experts question wisdom of stockpiling oseltamivir

London

Stockpiling supplies of the antiviral drug oseltamivir (Tamiflu) for use in the event of a flu epidemic was questioned by experts on both sides of the Atlantic this week.

The UK government's decision to order 14.6 million doses of oseltamivir was questioned by Joe Collier, professor of medicines policy at St George's Hospital Medical School, London, and former editor of the Drug and Therapeutics Bulletin.

"I would like to know what evidence there is that Tamiflu actually alters mortality," he said. "And if it doesn't then what are we doing? What it certainly does is shorten the illness by a day, but the question is—does that matter?"

On the other side of the Atlantic Canada's federal health minister, Ujjal Dosanjh, told listeners to an interview on a Canadian Broadcasting Corporation radio programme ("The Current," 27 Oct) that oseltamivir did not prevent infection with the flu virus and that at best it would reduce the severity of the illness ( BMJ 2003;326: 1235[Abstract/Free Full Text]).

The demand for oseltamivir has risen dramatically in recent months amid fears of the spread of avian flu, which has led to more than 60 deaths in east Asia and the culling of 150 million birds. The drug's manufacturer, Roche, recently suspended supplies to pharmacies in Canada and the United States to protect stocks for use when the flu season begins.

In the United Kingdom the drug is increasingly advertised online, and pharmacies have reported a big increase in inquiries from the public. Although GPs are currently able to prescribe it on the NHS only if someone has both flu and a chronic condition, any patient who gets a private prescription for the drug can obtain it from a pharmacist for £25 for a pack of 10 pills.

The UK health department says that oseltamivir will be the "first line of defence" for the treatment of flu if there is a pandemic. Apart from ordering 14.6 million doses of the drug from Roche to be produced by September 2006, it has arranged for larger than normal amounts to be made available this winter to treat people who are at highest risk from current strains of flu.

In response to rising demand Roche has increased production of the drug by nearly 10-fold in the last 2.5 years. It is expected to record sales of $925m (£522m; 770m), more than three times last year's $266m.

The spokeswoman also confirmed that the department was at an advanced stage of discussions about licensing other companies to make the drug to increase overall supplies. More than 100 companies had contacted the department in the last fortnight to offer their services, she said.

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