BMJ  2005;331 (20 August), doi:10.1136/bmj.331.7514.0-c

Cognitive behaviour therapy reduces symptom severity of irritable bowel syndrome

Cognitive behaviour therapy plus the antispasmodic drug mebeverine reduces symptom severity for up to six months in people with irritable bowel syndrome. Kennedy and colleagues (p 435) randomised 149 patients who had not responded to mebeverine to cognitive behaviour therapy delivered by primary care nurses plus mebeverine or to mebeverine alone. The mean reduction in symptom severity score associated with adding cognitive behaviour therapy was 68 points (95% confidence interval 103 to 33) at 1.5 months, but by 12 months the effect was no longer apparent.

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Cognitive behaviour therapy in addition to antispasmodic treatment for irritable bowel syndrome in primary care: randomised controlled trial

Tom Kennedy, Roger Jones, Simon Darnley, Paul Seed, Simon Wessely, and Trudie Chalder
BMJ 2005 331: 435. [Abstract] [Full Text] [PDF]