BMJ  2005;331 (16 July), doi:10.1136/bmj.331.7509.0

Chromosome analysis in miscarriages could be more selective

Multiple factors influence the probability of structural chromosome abnormalities in a couple trying to conceive. In a nested case control study that included 279 carrier couples (cases) and 428 non-carrier couples (controls), Franssen and colleagues (p 137) identified additional independent factors: low maternal age at the time of second miscarriage, a history of three or more miscarriages, and a history of two or more miscarriages in siblings or parents of either partner. Selective chromosome analysis could reduce the number of chromosome analyses by 18%, thus lowering the costs.

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Selective chromosome analysis in couples with two or more miscarriages: case-control study

Maureen T M Franssen, Johanna C Korevaar, Nico J Leschot, Patrick M M Bossuyt, Alida C Knegt, Klasien B J Gerssen-Schoorl, Cokkie H Wouters, Kerstin B M Hansson, Ron Hochstenbach, Kamlesh Madan, Fulco van der Veen, and Mariette Goddijn
BMJ 2005 331: 137-141. [Abstract] [Full Text] [PDF]

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