Relative risk (95% confidence interval) of schizophrenia and schizophrenia-like psychosis associated with epilepsy and family history of psychosis and epilepsy

Schizophrenia Schizophrenia-like psychoses Variable Crude Adjusted* Crude Adjusted* Personal history of epilepsy: No (reference) 1 1 1 1 Yes 2.60 (2.31 to 2.93) 2.48 (2.20 to 2.80) 2.98 (2.73 to 3.25) 2.93 (2.69 to 3.20) Family history of psychosis: No (reference) 1 1 1 1 Schizophrenia 8.43 (7.78 to 9.13) 7.57 (6.98 to 8.20) 6.77 (6.32 to 7.25) 6.24 (5.83 to 6.69) Schizophrenia-like psychosis 4.63 (4.22 to 5.09) 4.28 (3.89 to 4.70) 4.29 (3.97 to 4.62) 4.03 (3.73 to 4.35) Affective psychosis 2.33 (2.17 to 2.50) 2.25 (2.10 to 2.42) 2.34 (2.22 to 2.47) 2.27 (2.15 to 2.40) Family history of epilepsy: No (reference) 1 1 1 1 Yes 1.28 (1.16 to 1.41) 1.11 (1.01 to 1.22) 1.34 (1.25 to 1.44) 1.20 (1.11 to 1.29)

P=0.04 for schizophrenia-like psychosis.

^* Adjusted for age, sex, calendar year of diagnosis, place of birth, paternal and maternal age at birth, and birth order as well all variables in table. Test of interaction, based on the adjusted analyses—sex and epilepsy: P=0.31 for schizophrenia, P=0.51 for schizophrenia-like psychosis; age and epilepsy: P=0.01 for schizophrenia,

P<0.01.

P<0.05.