BMJ  2005;330 (11 June), doi:10.1136/bmj.330.7504.0-b

NSAIDs may be cardiotoxic

The cardiovascular safety of non-steroidal anti-inflammatory drugs (NSAIDs) needs to be reconsidered. In a nested case-control analysis, Hippisley-Cox and Coupland (p 1366) determined the comparative risk of myocardial infarction in patients taking cyclo-oxygenase-2 (COX 2) inhibitors and NSAIDs. All drugs in the study were associated with an increased risk of myocardial infarction, which was statistically significant for rofecoxib, diclofenac, and ibuprofen; no protective effect was seen for naproxen. The authors warn that this is an observational study and may be subject to residual confounding that cannot be fully corrected for.

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Relevant Article

Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis

Julia Hippisley-Cox and Carol Coupland
BMJ 2005 330: 1366. [Abstract] [Full Text] [PDF]

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puzzled of oldmeldrum

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Nested in a nutshell

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