BMJ  2005;330 (11 June), doi:10.1136/bmj.330.7504.0-b

NSAIDs may be cardiotoxic

The cardiovascular safety of non-steroidal anti-inflammatory drugs (NSAIDs) needs to be reconsidered. In a nested case-control analysis, Hippisley-Cox and Coupland (p 1366) determined the comparative risk of myocardial infarction in patients taking cyclo-oxygenase-2 (COX 2) inhibitors and NSAIDs. All drugs in the study were associated with an increased risk of myocardial infarction, which was statistically significant for rofecoxib, diclofenac, and ibuprofen; no protective effect was seen for naproxen. The authors warn that this is an observational study and may be subject to residual confounding that cannot be fully corrected for.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    StumbleUpon    Technorati    What's this?

Relevant Article

Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis

Julia Hippisley-Cox and Carol Coupland
BMJ 2005 330: 1366. [Abstract] [Full Text] [PDF]

Rapid Responses:

Read all Rapid Responses

puzzled of oldmeldrum

David G Connell
bmj.com, 10 Jun 2005 [Full text]

Re: puzzled of oldmeldrum

Hasan Rizvi
bmj.com, 11 Jun 2005 [Full text]

Nested in a nutshell

David Potterton
bmj.com, 11 Jun 2005 [Full text]

Online poll

Find out more >>