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BMJ 2005;330 (16 April), doi:10.1136/bmj.330.7496.0-e
Cohort studies offer important advantages over randomised controlled trials, like determining if the efficacy observed in randomised controlled trials translates into effectiveness in broader populations and more realistic settings, and to provide information on adverse events and risks. In the first of three articles on critical appraisal of cohort studies, Gurwitz and colleagues (p 895) explain the role of cohort studies in the hierarchy of evidence, the characteristics of their design, and how selection bias can compromise their validity.
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