BMJ  2005;330 (26 March), doi:10.1136/bmj.330.7493.0

HIV patients need new antiretroviral drugs

Some HIV infected patients taking highly active antiretroviral therapy may be in danger of exhausting their treatment options, and new drugs with low toxicity to which the virus is not resistant need to be developed urgently. In a multicentre cohort study lasting seven years and including 16 593 patients in southeast England, Sabin and colleagues (p 695) assessed the association of exposure to antiretroviral drugs, CD4 cell count, and plasma HIV RNA burden. Although patients' immunological and virological status generally improved, a small but growing proportion of patients seemed to be in danger of exhausting current treatment options.

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Relevant Article

Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study

Caroline A Sabin, Teresa Hill, Fiona Lampe, Ryanne Matthias, Sanjay Bhagani, Richard Gilson, Mike S Youle, Margaret A Johnson, Martin Fisher, George Scullard, Philippa Easterbrook, Brian Gazzard, Andrew N Phillips on behalf of the steering committee of the UK Collaborative HIV Cohort Study Group
BMJ 2005 330: 695. [Abstract] [Full Text] [PDF]

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