BMJ  2005;330 (12 March), doi:10.1136/bmj.330.7491.0-b

Use PPIs in bleeding ulcer

Treating patients who have bleeding ulcers with proton pump inhibitors reduces complications. Reviewing 21 randomised controlled trials including 2915 patients, Leontiadis and colleagues (p 568) found that patients who were treated with a proton pump inhibitor were less likely to rebleed or need surgery after the initial gastric bleeding, than were those treated with an H₂ receptor antagonist or placebo. Meta-analysis showed that treatment with proton pump inhibitors had no significant effect on mortality.

Credit: DAVID M MARTIN/SPL

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Relevant Article

Systematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding

Grigoris I Leontiadis, Virender K Sharma, and Colin W Howden
BMJ 2005 330: 568. [Abstract] [Full Text] [PDF]