Use PPIs in bleeding ulcer

doi:10.1136/bmj.330.7491.0-b

BMJ 2005;330 (12 March), doi:10.1136/bmj.330.7491.0-b

Use PPIs in bleeding ulcer

Treating patients who have bleeding ulcers with proton pumpinhibitors reduces complications. Reviewing 21 randomised controlledtrials including 2915 patients, Leontiadis and colleagues (p 568)found that patients who were treated with a proton pumpinhibitor were less likely to rebleed or need surgery afterthe initial gastric bleeding, than were those treated with anH₂ receptor antagonist or placebo. Meta-analysis showed thattreatment with proton pump inhibitors had no significant effecton mortality.