BMJ  2005;330 (5 March), doi:10.1136/bmj.330.7490.0-a

Tacrolimus 0.1% matches potent steroids in eczema

Topical tacrolimus 0.1% is as effective in treating atopic dermatitis as potent corticosteroids and more effective than mild corticosteroids, and its side effects seem to be less serious, although it causes more skin burning. Ashcroft and colleagues (p 516) performed a meta-analysis of 25 randomised controlled trials including 6897 patients. They found no evidence that tacrolimus or pimecrolimus increases the risk of skin infection, but data are lacking for firm conclusions on whether they offer any advantage over corticosteroids in long term treatment of atopic dermatitis.

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Relevant Article

Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials

Darren M Ashcroft, Paul Dimmock, Ruth Garside, Ken Stein, and Hywel C Williams
BMJ 2005 330: 516. [Abstract] [Full Text] [PDF]

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