BMJ  2005;330 (26 February), doi:10.1136/bmj.330.7489.0

Choice of antipsychotics for dementia doesn't affect risk of stroke

The choice between atypical and typical antipsychotic drugs to manage behavioural and psychological symptoms of dementia in elderly people should not be based on concerns about the risk of stroke. In a population based retrospective cohort study including 32 710 people aged 65 years and older, Gill and colleagues (p 445) compared the incidence of stroke in those taking atypical and typical antipsychotics. After adjusting for potential confounders, they found no difference in risk of ischaemic stroke (adjusted hazard ratio 1.01, 95% confidence interval 0.81 to 1.26).

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Relevant Article

Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study

Sudeep S Gill, Paula A Rochon, Nathan Herrmann, Philip E Lee, Kathy Sykora, Nadia Gunraj, Sharon-Lise T Normand, Jerry H Gurwitz, Connie Marras, Walter P Wodchis, and Muhammad Mamdani
BMJ 2005 330: 445. [Abstract] [Full Text] [PDF]

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