Table 1 Effect of hormone replacement therapy on stroke and its type and outcome, and transient ischaemic attack

No of trials No of subjects No of events Control event rate (%) Odds ratio* (95% CI), P value Heterogeneity (P value) Stroke: 28 39 769 940 2.03 1.29 (1.13 to 1.47), 0.0002 0.56 Ischaemic 16 23 426 443 1.59 1.29 (1.06 to 1.56), 0.01 0.59 Haemorrhagic 17 23 690 63 0.25 1.07 (0.65 to 1.75), 0.79 0.75 Transient ischaemic attack 22 10 050 233 2.13 1.02 (0.78 to 1.34), 0.86 0.86 Outcome: Fatal 22 36 430 129 0.29 1.28 (0.87 to 1.88), 0.21 0.39 Non-fatal 21 36 230 710 1.72 1.23 (1.06 to 1.44), 0.007 0.45 Death or dependency 14 20 445 145 0.53 1.56 (1.11 to 2.20), 0.01 0.93

^* Odds ratios calculated with random effects model.