Enrolment period Study design Eligible patients Intervention No of patients June 1973 to September 1975 Randomised controlled trial Node positive, premenopausal, and postmenopausal Surgery v CMF for 12 cycles 179 v 207 September 1975 to May 1978 Randomised controlled trial Node positive, premenopausal CMF for 12 cycles v CMF for 6 cycles 160 v 164 May 1978 to October 1980 Observational study Node positive, premenopausal CMF for 12 cycles 220 December 1980 to October 1985 Randomised controlled trial Node negative and oestrogen receptor negative, premenopausal, and postmenopausal Surgery v intravenous CMF for 12 cycles 45 v 45