BMJ  2004;329 (23 October), doi:10.1136/bmj.329.7472.0-c

More than one drug protects the stomach from NSAIDs

Different therapeutic options are available to protect the stomach in people using nonsteroidal anti-inflammatory drugs (NSAIDs). Reviewing more than 100 trials on gastroprotective strategies for people taking NSAIDs, Hooper and colleagues (p 948) found that misoprostol and COX-2 specific and selective NSAIDs (and probably proton pump inhibitors) reduce the risk of symptomatic ulcers. Misoprostol (and probably COX-2 NSAIDs) reduce the risk of serious gastrointestinal complications, but data quality is low. Data on H₂ receptor antagonists and proton pump inhibitors are not conclusive.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    StumbleUpon    Technorati    What's this?

Relevant Article

The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review

Lee Hooper, Tamara J Brown, Rachel Elliott, Katherine Payne, Chris Roberts, and Deborah Symmons
BMJ 2004 329: 948. [Abstract] [Full Text] [PDF]

Online poll

Find out more >>