BMJ  2004;329 (9 October), doi:10.1136/bmj.329.7470.0-a

Use ACE inhibitors in patients with diabetic nephropathy

Angiotensin converting enzyme (ACE) inhibitors may be the best choice for patients with diabetic nephropathy. Reviewing 43 trials, Strippoli and colleagues (p 828) found that ACE inhibitors, but not angiotensin II receptor antagonists, improved survival of these patients. The drugs had a similar effect on renal function. Because of the lack of good quality trials, the relative effects of ACE inhibitors and angiotensin II receptor blockers on survival is not known.

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Relevant Article

Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review

Giovanni F M Strippoli, Maria Craig, Jonathan J Deeks, Francesco Paolo Schena, and Jonathan C Craig
BMJ 2004 329: 828. [Abstract] [Full Text] [PDF]